Feeling Drained? Why Your Lifestyle Might Be Tanking Your Testosterone (And How to Fight Back Naturally)
Alright guys, let's talk about something that hits close to home for many of us as we get older: that feeling of running on fumes. Maybe the energy isn't what it used to be, the mental fog rolls in more often, or that spark, that drive, just feels... dimmer. It's easy to chalk it up to just "getting older," but often, there's more to the story, and a key player could be testosterone.
We hear a lot about "Low T" these days, often linked to aging. And yes, it's true that testosterone levels naturally decline gradually as men age, typically starting around age 30 or 40.1 But here’s the crucial part that often gets missed: this natural decline is often accelerated and made significantly worse by lifestyle factors. Things like carrying extra weight and not getting enough quality sleep can hit your T levels much harder than the passing years alone.4
The good news? You have more control than you think. This isn't about fighting an inevitable decline with quick fixes. It's about understanding how your daily habits impact this vital hormone and empowering you to make changes that not only support healthy testosterone levels but boost your overall health and vitality for the long haul. Forget the hype around miracle cures – the most powerful tools are already in your hands: your diet and your activity levels. Let's dive in.
Testosterone: More Than Just Muscle and Sex Drive
Before we talk about fixing low levels, let's quickly cover why healthy testosterone matters. It's often pigeonholed as the "sex hormone," and while it definitely fuels libido and sexual function 7, its influence extends far beyond the bedroom.
Testosterone is a powerhouse hormone involved in:
- Energy and Vitality: That get-up-and-go feeling? Testosterone plays a big role.3 Low levels are often linked to fatigue and lack of motivation.3
- Mood and Mental Clarity: It influences mood, concentration, and even confidence.10 Low T can contribute to irritability or feeling down.3
- Muscle Mass and Strength: It's crucial for building and maintaining muscle.10
- Bone Health: Testosterone (partly through conversion to estrogen) helps keep bones strong and dense, reducing fracture risk later in life.17
- Fat Distribution and Metabolism: It helps regulate where your body stores fat and plays a role in overall metabolic health, including insulin sensitivity.1
Maintaining healthy testosterone levels isn't just about feeling "manly"; it's fundamental to your overall physical and mental well-being as you age.0
The Twin Thieves: How Excess Fat and Poor Sleep Sabotage Your T Levels
While aging causes a slow dip, two major lifestyle factors act like accelerators on that decline: excess body fat and poor sleep. Understanding how they work is key to fighting back.
Primary Culprit #1: Excess Body Fat – The Testosterone Thief
This is arguably the single biggest lifestyle factor hammering male testosterone levels.5 There's a strong, consistent inverse relationship: the more excess body fat you carry, especially around the belly (visceral fat), the lower your testosterone is likely to be.1 It's estimated that a significant portion, potentially 40-50% or even more in severe cases, of overweight or obese men have clinically low testosterone levels.8
How does fat steal your T? It's a multi-pronged attack:
- The Estrogen Conversion Factory: Excess fat tissue, particularly visceral fat, is packed with an enzyme called aromatase. This enzyme's job is to convert testosterone into estradiol, a form of estrogen.5 More fat means more aromatase, meaning more of your precious testosterone gets turned into estrogen. Elevated estrogen then sends a signal back to your brain telling it to slow down testosterone production – a classic negative feedback loop.5
- Inflammation Overload: Obesity isn't just about extra weight; it's often a state of chronic, low-grade inflammation. Dysfunctional fat cells pump out inflammatory messengers (cytokines like TNF-α and IL-6).5 This constant inflammation can disrupt the delicate signaling cascade (the hypothalamic-pituitary-gonadal, or HPG axis) that controls testosterone production, potentially by interfering with key signaling molecules like kisspeptin.5 Think of it as static on the hormonal communication lines.
- Insulin Resistance & SHBG Sabotage: Obesity frequently goes hand-in-hand with insulin resistance, where your cells don't respond properly to insulin.1 When insulin levels are chronically high (hyperinsulinemia), it signals your liver to produce less Sex Hormone-Binding Globulin (SHBG).32 SHBG acts like a taxi for testosterone in your bloodstream. Less SHBG means lower total testosterone levels.26 While free (unbound, active) testosterone might stay normal initially in moderate obesity, severe obesity tends to suppress the entire HPG axis, lowering free testosterone too.26 High insulin might also directly dampen the HPG axis via kisspeptin signals.5
- Leptin Gone Wrong: Leptin, a hormone from fat cells, normally helps signal the brain to stimulate testosterone pathways. But in obesity, the brain can become resistant to leptin's signals, impairing this supportive role.5
Crucially, this relationship is a two-way street, creating a vicious cycle. Obesity lowers testosterone, and low testosterone makes it harder to lose fat and easier to gain it, particularly visceral fat.5 Breaking this cycle requires decisive action – and that action usually involves shedding the excess weight.
Primary Culprit #2: Skimping on Sleep – Hormonal Havoc While You Snooze
Think of sleep as the crucial night shift for your body's hormone production crew. The vast majority of your daily testosterone release happens while you're asleep.6 Levels naturally peak in the morning after a restorative night, coinciding with REM sleep phases.37
Here's how messing with sleep messes with your T:
- Cutting Hours, Cutting T: Research is clear: restricting sleep takes a direct toll. One study found that limiting sleep to just 5 hours per night for only one week lowered daytime testosterone levels by a significant 10-15% in young, healthy men.6 To put that in perspective, that's a drop comparable to aging 10 to 15 years!.6 Other studies link longer sleep duration to higher testosterone levels.39
- Quality Trumps Quantity (Sometimes): It's not just about hours logged in bed. Fragmented sleep – waking up frequently, tossing and turning – disrupts the normal sleep architecture needed for that testosterone surge.6 Even if you're in bed for 8 hours, poor quality sleep can prevent the full hormonal restoration.
- The Sleep Apnea Link: Obstructive Sleep Apnea (OSA), a condition where breathing repeatedly stops and starts during sleep, is strongly linked to lower testosterone levels.40 OSA often accompanies obesity 15, making it hard to untangle the exact cause – is it the apnea itself, the associated poor sleep quality and oxygen dips, or the excess weight? Likely, it's a combination.38 Regardless, untreated OSA means chronically disrupted sleep and stress on the body, which isn't doing your hormones any favors. Improving sleep quality, sometimes through weight loss which can lessen apnea severity, offers a potential double win for T levels.
(A Quick Note on Stress): Chronic stress is another modern-day T-killer. Persistent stress keeps cortisol levels high, and cortisol acts like an anti-testosterone signal, suppressing production pathways.43 Managing stress through exercise, mindfulness, or other techniques adds another layer of support for hormonal balance.
Your Action Plan: Rebuilding T Levels Naturally
Feeling motivated to take control? Excellent. The power to positively influence your testosterone levels lies primarily in addressing those lifestyle factors. Here are your two most impactful moves:
Power Move #1: Win the Weight Battle
If you're carrying extra pounds, this is your number one priority. Losing excess body fat is arguably the single most effective natural strategy to boost your testosterone levels.5 We're not talking about needing to become a shredded bodybuilder; even moderate, sustained weight loss can lead to significant increases in T. In some cases, substantial weight loss can even reverse obesity-induced hypogonadism entirely.5
Why is it so effective? Because it directly tackles the mechanisms that were suppressing your T levels:
- Less Fat = Less Estrogen Conversion: Shrinking fat cells reduces aromatase activity, meaning less testosterone gets converted into estrogen.25
- Cooling Inflammation: Weight loss lowers the chronic inflammation associated with obesity, allowing your hormonal signaling pathways to function more smoothly.25
- Improving Insulin Sensitivity: Shedding pounds helps your body respond better to insulin, which can help normalize SHBG levels and support a healthier HPG axis function.25
How to do it? Sustainable changes are key. Focus on a whole-foods diet with plenty of protein, healthy fats, and fiber. While extreme diets might offer quick results, they're often hard to maintain. Some research suggests that low-carbohydrate approaches can be effective for weight loss and may increase T in that context 30, although combining very high protein with low carbs might potentially lower T.49 Conversely, very low-fat diets have been linked to decreased testosterone in some studies 51, suggesting that adequate healthy fats (from sources like avocados, nuts, olive oil) are important. Mediterranean-style diets also show promise.30 The best diet is one you can stick with long-term that creates a calorie deficit.
Power Move #2: Get Moving – Strategically
Exercise is your other cornerstone. It works synergistically with diet to improve body composition and metabolic health – the bedrock of hormonal balance.
- Lift Heavy Things (Resistance Training): Building and maintaining muscle mass is crucial. Muscle is metabolically active and helps improve your overall muscle-to-fat ratio, creating a more favorable hormonal environment.10 Plus, intense resistance exercise can provide a temporary boost in T levels post-workout.16
- Get Your Heart Pumping (Endurance/Aerobic Exercise): Cardio is vital for heart health, improving insulin sensitivity, and burning calories to aid weight management.48 Some studies even show small increases in baseline testosterone levels with regular aerobic or interval training.53
- Consistency Beats Intensity (Sometimes): Aim for regular activity you enjoy. A mix of resistance training (2-3 times/week) and cardio is ideal. Don't fall into the trap of overtraining – pushing yourself too hard without adequate recovery can actually lower testosterone due to chronic stress.45
One study powerfully illustrated exercise's impact: it found that exercise training was more effective than testosterone treatment for improving aerobic fitness and reducing body fat in middle-to-older aged men with low-normal T levels. Adding testosterone only provided an extra edge for increasing lean mass.52 The takeaway? Exercise delivers broad benefits that T therapy alone can't match.
The Bigger Picture: Low T is Often a Health Warning Sign
It's important to shift perspective: low testosterone isn't always the root problem, but often a symptom or indicator of broader health issues, particularly metabolic dysfunction.1
Low T levels are strongly associated with:
- Metabolic Syndrome: A cluster of conditions (high blood pressure, high blood sugar, unhealthy cholesterol levels, excess belly fat) that increase heart disease and diabetes risk.
- Insulin Resistance and Type 2 Diabetes: Low T often precedes or accompanies these conditions.33
- Increased Cardiovascular Risk: Studies link low T to higher risks of heart disease and overall mortality.4
Here’s the empowering part: the very same lifestyle strategies we've discussed – eating well, losing excess weight, exercising regularly, and prioritizing sleep – are exactly what you need to do to address these underlying metabolic issues.33 By focusing on these foundational habits, you're not just trying to nudge one hormone number; you're making a powerful investment in your overall, long-term health, reducing your risk of serious diseases, and boosting your energy and vitality from the ground up.
Testosterone Replacement Therapy (TRT): Understanding the Tool and Its Place
With the rise of "Low T" clinics and direct-to-consumer advertising, it's crucial to understand what Testosterone Replacement Therapy (TRT) is, who it's for, and its potential risks.
TRT is a legitimate medical treatment, but it's specifically indicated for men with diagnosed clinical hypogonadism. This means having consistently and unequivocally low testosterone levels (confirmed by multiple morning blood tests) combined with significant, bothersome symptoms like severe loss of libido, erectile dysfunction, unexplained fatigue, or loss of muscle mass.8
For men who genuinely meet these criteria, TRT can offer benefits, potentially improving energy levels, sex drive, mood, muscle mass, and bone density.7 Some studies also suggest improvements in body composition and insulin sensitivity in specific hypogonadal populations.23
However, TRT is not without risks, and the benefit/risk calculation changes significantly when considering it for milder, age-related declines or without a confirmed diagnosis:
- Cardiovascular Concerns: This remains a debated area. Early studies raised alarms about increased heart attack and stroke risk, leading to FDA warnings.59 While more recent, large meta-analyses and trials have often shown no increased risk (or even potential benefits) in appropriately selected hypogonadal men 18, uncertainty persists. Caution is especially warranted for men with existing heart conditions.59
- Prostate Health: Testosterone fuels prostate tissue. TRT can worsen symptoms of an enlarged prostate (BPH).65 While current evidence suggests TRT doesn't cause prostate cancer in hypogonadal men 71, it can stimulate the growth of existing cancer, making it contraindicated for men with the disease.11 Careful monitoring (PSA tests) is essential if TRT is used.36
- Blood Clots: TRT can increase the risk of deep vein thrombosis (DVT) and pulmonary embolism (PE).65
- Sleep Apnea: It can worsen untreated or severe sleep apnea.38
- Other Side Effects: Increased red blood cell count (potentially thickening blood), acne, hair loss, breast enlargement (gynecomastia), and suppression of natural sperm production, leading to infertility.10
A major concern is the trend of TRT overprescription.69 Prescriptions have skyrocketed, often driven by marketing targeting age-related symptoms like fatigue or a desire for enhanced physique, rather than confirmed medical need.4 Many men receive TRT without proper testing or consideration of lifestyle interventions first.4 Both the FDA and the Endocrine Society explicitly caution against using TRT solely to combat aging.36
Given the potential risks and the lack of clear benefit for men who aren't clinically hypogonadal, TRT should not be viewed as a first-line approach or a shortcut to bypass healthy habits. Lifestyle changes address the root causes of much age- and lifestyle-related T decline (obesity, inflammation, poor sleep, insulin resistance) and offer far broader health benefits with significantly fewer risks.52
Take the Reins – Your Health is in Your Hands
Feeling less energetic or vital as the years go by isn't something you just have to accept. While testosterone naturally declines with age, your lifestyle choices hold immense power to influence its trajectory. Excess weight and poor sleep are the primary culprits accelerating this decline for many men.
The path to reclaiming your vitality and supporting healthy hormone levels isn't found in a miracle pill or injection for most guys. It's built on the foundation of sustainable, healthy habits:
- Achieve and Maintain a Healthy Weight: This is paramount. Focus on nutritious food choices and portion control. Talk to your Myrtle Beach Murrells Inlet Nutrition Coach today!
- Move Your Body Regularly: Incorporate both resistance training to build muscle and aerobic exercise for heart health and calorie burn.
- Prioritize Quality Sleep: Aim for 7-9 hours of consistent, restorative sleep per night. Address potential issues like sleep apnea.
- Manage Stress: Find healthy outlets to cope with chronic stress.
These aren't just strategies for testosterone; they are the cornerstones of overall male health, reducing your risk of major diseases and boosting your energy, mood, and longevity.
Start small, be consistent, and focus on the long game. If you're experiencing persistent symptoms that concern you, talk to your doctor.11 They can perform proper testing, help rule out other underlying conditions, and discuss the most appropriate strategies for you, ensuring that any treatment decisions, including whether TRT is even a consideration, are based on genuine medical need and a clear understanding of the risks and benefits. Your health is worth the effort. Take the reins.
Works cited
- Long-Term Testosterone Administration on Insulin Sensitivity in Older Men With Low or Low-Normal Testosterone Levels - Oxford Academic, accessed April 21, 2025, https://academic.oup.com/jcem/article/103/4/1678/4822914
- Age-related testosterone decline: mechanisms and intervention strategies - PMC, accessed April 21, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC11562514/
- Testosterone for the aging male; current evidence and recommended practice - PMC, accessed April 21, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC2544367/
- The implications of low testosterone on mortality in men - PMC - PubMed Central, accessed April 21, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC4323275/
- Male Obesity-related Secondary Hypogonadism – Pathophysiology ..., accessed April 21, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC6785957/
- Effect of 1 Week of Sleep Restriction on Testosterone Levels in Young Healthy MenFREE, accessed April 21, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC4445839/
- An updated systematic review and meta-analysis of the effects of testosterone replacement therapy on erectile function and prostate, accessed April 21, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC10853420/
- Testosterone Deficiency, Cardiac Health, and Older Men - PMC, accessed April 21, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC4000629/
- Mayo Clinic Minute - How low testosterone can affect men's health - YouTube, accessed April 21, 2025, https://www.youtube.com/watch?v=GRxb6-CyPxM
- Testosterone therapy: Potential benefits and risks as you age - Mayo Clinic, accessed April 21, 2025, https://www.mayoclinic.org/healthy-lifestyle/sexual-health/in-depth/testosterone-therapy/art-20045728
- Male menopause: Myth or reality? - Mayo Clinic, accessed April 21, 2025, https://www.mayoclinic.org/healthy-lifestyle/mens-health/in-depth/male-menopause/art-20048056
- Male hypogonadism - Symptoms & causes - Mayo Clinic, accessed April 21, 2025, https://www.mayoclinic.org/diseases-conditions/male-hypogonadism/symptoms-causes/syc-20354881
- Testosterone Deficiency Guideline - American Urological Association, accessed April 21, 2025, https://www.auanet.org/guidelines-and-quality/guidelines/testosterone-deficiency-guideline
- The benefits and risks of testosterone replacement therapy: a review - PMC, accessed April 21, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC2701485/
- Low Testosterone (Low T): Causes, Symptoms & Treatment - Cleveland Clinic, accessed April 21, 2025, https://my.clevelandclinic.org/health/diseases/15603-low-testosterone-male-hypogonadism
- Testosterone physiology in resistance exercise and training: the up-stream regulatory elements - PubMed, accessed April 21, 2025, https://pubmed.ncbi.nlm.nih.gov/21058750/
- Battle of the sex steroids in the male skeleton: and the winner is… - JCI, accessed April 21, 2025, https://www.jci.org/articles/view/85006
- Testosterone and Male Bone Health: A Puzzle of Interactions - Oxford Academic, accessed April 21, 2025, https://academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgaf191/8090450
- Male Hypogonadism and Osteoporosis: The Effects, Clinical Consequences, and Treatment of Testosterone Deficiency in Bone Health - PMC - PubMed Central, accessed April 21, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC5376477/
- Revisiting the role of testosterone: Are we missing something? - PMC - PubMed Central, accessed April 21, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC5434832/
- Low Testosterone—An Important Predictor of Low Mineral Bone Density in Young Men—Our Own Experience and a Review of Literature, accessed April 21, 2025, https://www.scirp.org/journal/paperinformation?paperid=35410
- Testosterone and Bone Health in Men: A Narrative Review - PMC, accessed April 21, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC7867125/
- Effects of Testosterone Administration on Fat Distribution, Insulin Sensitivity, and Atherosclerosis Progression | Clinical Infectious Diseases | Oxford Academic, accessed April 21, 2025, https://academic.oup.com/cid/article/37/Supplement_2/S142/335512?login=true
- Low Testosterone Associated With Obesity and the Metabolic Syndrome Contributes to Sexual Dysfunction and Cardiovascular Disease Risk in Men With Type 2 Diabetes, accessed April 21, 2025, https://diabetesjournals.org/care/article-abstract/34/7/1669/38648
- Impact of Weight Loss on Testosterone Levels: A Review of BMI and Testosterone - PMC, accessed April 21, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC11745839/
- Lowered testosterone in male obesity: mechanisms, morbidity and management - PubMed, accessed April 21, 2025, https://pubmed.ncbi.nlm.nih.gov/24407187/
- Testosterone and weight loss: the evidence - PMC - PubMed Central, accessed April 21, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC4154787/
- Determinants of testosterone levels in human male obesity - PMC - PubMed Central, accessed April 21, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC4546699/
- Testosterone and obesity - PubMed, accessed April 21, 2025, https://pubmed.ncbi.nlm.nih.gov/25982085/
- Impact of Weight Loss on Testosterone Levels: A Review of BMI and Testosterone - PubMed, accessed April 21, 2025, https://pubmed.ncbi.nlm.nih.gov/39840189/
- Obesity and androgens: facts and perspectives - PubMed, accessed April 21, 2025, https://pubmed.ncbi.nlm.nih.gov/16647374/
- Lowered testosterone in male obesity: mechanisms, morbidity and ..., accessed April 21, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC3955331/
- Low Testosterone Associated With Obesity and the Metabolic Syndrome Contributes to Sexual Dysfunction and Cardiovascular Disease Risk in Men With Type 2 Diabetes - PubMed Central, accessed April 21, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC3120209/
- pmc.ncbi.nlm.nih.gov, accessed April 21, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC3120209/#:~:text=Visceral%20adiposity%20present%20in%20men,CVD)%20risk%20and%20erectile%20dysfunction.
- Low Testosterone Levels Are Common and Associated with Insulin Resistance in Men with Diabetes | The Journal of Clinical Endocrinology & Metabolism | Oxford Academic, accessed April 21, 2025, https://academic.oup.com/jcem/article/93/5/1834/2598879
- Testosterone Therapy in Men With Hypogonadism: An Endocrine Society* Clinical Practice Guideline - Oxford Academic, accessed April 21, 2025, https://academic.oup.com/jcem/article/103/5/1715/4939465
- Cross-sectional analysis of sleep hours and quality with sex hormones in men - PMC, accessed April 21, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC6376994/
- The relationship between sleep disorders and testosterone in men ..., accessed April 21, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC3955336/
- Sleep duration and testosterone levels in community older men: results from the West China Health and Aging Trend study, accessed April 21, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC10228469/
- The Association of Testosterone Levels with Overall Sleep Quality, Sleep Architecture, and Sleep-Disordered Breathing - PubMed Central, accessed April 21, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC2453053/
- The association of testosterone levels with overall sleep quality, sleep architecture, and sleep-disordered breathing - PubMed, accessed April 21, 2025, https://pubmed.ncbi.nlm.nih.gov/18413429/
- Obstructive Sleep Apnea and Testosterone Deficiency - PMC - PubMed Central, accessed April 21, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC6305865/
- Full article: Salivary testosterone and cortisol response in acute stress modulated by seven sessions of mindfulness meditation in young males - Taylor & Francis Online, accessed April 21, 2025, https://www.tandfonline.com/doi/full/10.1080/10253890.2024.2316041
- Stress Induced Cortisol Release Depresses The Secretion of Testosterone in Patients With Type 2 Diabetes Mellitus - PubMed Central, accessed April 21, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC9830570/
- How Does Stress Affect Testosterone Levels? - Medichecks, accessed April 21, 2025, https://www.medichecks.com/blogs/mental-health/how-can-stress-affect-testosterone-levels
- How Chronic Stress Impacts Your Testosterone Levels - Posterity Health, accessed April 21, 2025, https://posterityhealth.com/how-chronic-stress-impacts-your-testosterone-levels/
- High Stress Can Cause Testosterone to Drop - SynergenX Health, accessed April 21, 2025, https://synergenxhealth.com/low-testosterone-treatment-high-stress-can-cause-testosterone-drop/
- Lifestyle modification increases serum testosterone level and decrease central blood pressure in overweight and obese men - PubMed, accessed April 21, 2025, https://pubmed.ncbi.nlm.nih.gov/25753766/
- Low-carbohydrate diets and men's cortisol and testosterone: Systematic review and meta-analysis - PubMed, accessed April 21, 2025, https://pubmed.ncbi.nlm.nih.gov/35254136/
- High-protein diets and testosterone - PubMed, accessed April 21, 2025, https://pubmed.ncbi.nlm.nih.gov/36266956/
- Low-fat diets and testosterone in men: Systematic review and meta-analysis of intervention studies - PubMed, accessed April 21, 2025, https://pubmed.ncbi.nlm.nih.gov/33741447/
- effects on fitness, body composition, and strength in middle-to-older aged men with low-normal serum testosterone levels - PubMed, accessed April 21, 2025, https://pubmed.ncbi.nlm.nih.gov/33739155/
- Short-Term Exercise Training Inconsistently Influences Basal Testosterone in Older Men: A Systematic Review and Meta-Analysis - PubMed, accessed April 21, 2025, https://pubmed.ncbi.nlm.nih.gov/30692929/
- Endurance training and testosterone levels - PubMed, accessed April 21, 2025, https://pubmed.ncbi.nlm.nih.gov/2675257/
- View of Cardiovascular benefits and risks of testosterone replacement therapy in hypogonadal men with type 2 diabetes mellitus and/or the metabolic syndrome: a systematic review, accessed April 21, 2025, https://bjd-abcd.com/index.php/bjd/article/view/286/547
- Low testosterone associated with obesity and the metabolic syndrome contributes to sexual dysfunction and cardiovascular disease risk in men with type 2 diabetes - PubMed, accessed April 21, 2025, https://pubmed.ncbi.nlm.nih.gov/21709300/
- Low Serum Testosterone and Mortality in Older Men - PMC - PubMed Central, accessed April 21, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC2190742/
- Endogenous Testosterone and Mortality in Men: A Systematic Review and Meta-Analysis - PMC - PubMed Central, accessed April 21, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC3200249/
- Testosterone therapy in hypogonadal men: a systematic review and network meta-analysis - PMC - PubMed Central, accessed April 21, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC5701987/
- Testosterone Therapy for Hypogonadism Guideline Resources - Endocrine Society, accessed April 21, 2025, https://www.endocrine.org/clinical-practice-guidelines/testosterone-therapy
- THE TRUTH ABOUT TESTOSTERONE TREATMENTS - Endocrine Society, accessed April 21, 2025, https://www.endocrine.org/-/media/endocrine/files/patient-engagement/patient-guides/patient_guide_the_truth_about_testosterone_treatments.pdf
- Testosterone Therapy in Men With Hypogonadism: An Endocrine Society Clinical Practice Guideline - PubMed, accessed April 21, 2025, https://pubmed.ncbi.nlm.nih.gov/29562364/
- Testosterone replacement therapy improves insulin sensitivity and decreases high sensitivity C-reactive protein levels in hypogonadotropic hypogonadal young male patients - PubMed, accessed April 21, 2025, https://pubmed.ncbi.nlm.nih.gov/20092788/
- Insulin Resistance and Inflammation in Hypogonadotropic Hypogonadism and Their Reduction After Testosterone Replacement in Men With Type 2 Diabetes, accessed April 21, 2025, https://diabetesjournals.org/care/article/39/1/82/31792/Insulin-Resistance-and-Inflammation-in
- Testosterone Replacement Therapy: Injections, Patches, and Gels - WebMD, accessed April 21, 2025, https://www.webmd.com/men/testosterone-replacement-therapy-is-it-right-for-you
- Testosterone and the Heart - PMC, accessed April 21, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC5512682/
- Testosterone Treatment, A Risky Bet? | Cognitive Vitality, accessed April 21, 2025, https://www.alzdiscovery.org/cognitive-vitality/blog/testosterone-treatment-a-risky-bet
- Testosterone Replacement Therapy: Controversy and Recent Trends - U.S. Pharmacist, accessed April 21, 2025, https://www.uspharmacist.com/article/testosterone-replacement-therapy-controversy-and-recent-trends
- Health Risks Linked To Overprescription Of Testosterone Therapy | MedTruth, accessed April 21, 2025, https://medtruth.com/articles/news/testosterone-therapy-risks/
- TESTOSTERONE REPLACEMENT THERAPY AND CARDIOVASCULAR OUTCOMES IN MEN: AN UPDATED META-ANALYSIS OF 9112 PATIENTS | JACC, accessed April 21, 2025, https://www.jacc.org/doi/10.1016/S0735-1097%2824%2903712-4
- Full article: Testosterone replacement therapy is not associated with increased prostate cancer incidence, prostate cancer-specific, or cardiovascular disease-specific mortality in Finnish men, accessed April 21, 2025, https://www.tandfonline.com/doi/full/10.1080/0284186X.2023.2278189
- Men too often receive T for 'soft' indications - Urology Times, accessed April 21, 2025, https://www.urologytimes.com/view/men-too-often-receive-t-soft-indications
- An updated systematic review and meta-analysis of the effects of testosterone replacement therapy on erectile function and prostate - Frontiers, accessed April 21, 2025, https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2024.1335146/full
- Testosterone and prostate cancer: an evidence-based review of pathogenesis and oncologic risk - PMC - PubMed Central, accessed April 21, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC4647137/
- Association between hormone replacement therapy and subsequent arterial and venous vascular events: a meta-analysis, accessed April 21, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC2515884/
- (PDF) Testosterone Replacement Therapy in Older Male Subjective Memory Complainers: Double-Blind Randomized Crossover Placebo-Controlled Clinical Trial of Physiological Assessment and Safety - ResearchGate, accessed April 21, 2025, https://www.researchgate.net/publication/275662061_Testosterone_Replacement_Therapy_in_Older_Male_Subjective_Memory_Complainers_Double-Blind_Randomized_Crossover_Placebo-Controlled_Clinical_Trial_of_Physiological_Assessment_and_Safety
- Rise of Testosterone Clinics Raises Concerns Over Side Effects and Safety - Martin Miner, accessed April 21, 2025, https://www.urotoday.com/imaging-center-coe-videos/4361-rise-of-testosterone-clinics-raises-concerns-over-side-effects-and-safety-martin-miner.html
- Testosterone replacement therapy is rising in popularity. What is it and what are there risks? - CBS News, accessed April 21, 2025, https://www.cbsnews.com/news/what-is-testosterone-replacement-therapy-risks/